For the beyond ten days I've collected wide latitude of an implemented lot of statistics about the treatment substitute probabilities for my spreading melanoma. I've spoken with three specially several oncologists about whether or not I need to have salvage chemotherapy, they customarily have in turn consulted with four other docs. Yesterday Dr. Apolo pronounced that she had consulted with two added docs, who agreed that ddMVAC was like minded, so the ultimate tally is 5 docs help dose dense MVAC, and two advise in festival to it. In addition, I have largely pointed out whether or not to proceed with Jennifer and Chelsea. I have prayed for solutions in, or at least convenience with, my resolution. Yesterday afternoon I determined to head forward with ddMVAC.
The themes that swung my resolution to head forward with treatment have been as follows: First, I trust the judgment of Drs. Apolo and Aragon-Ching. Although I additionally trust the judgment of Drs. Plimack and Steinberg, who've been advising in festival to treatment, I was as a cease result persuaded by overview of the literature, and in final outcomes of my cell conference with Dr. Apolo the former day.
Second, the reality that Dr. Apolo pronounced that she had examined the melanoma cells take from me right all by way of the biopsy a large wide latitude of weeks within of the beyond, and concluded that my metastatic melanoma was undifferentiated and greater competitive, delivered about me scale down payment the hope expressed by Dr. Plimack that my melanoma would in all likelihood circulate slowly by way of my physique. It appears to be love to be the classification of melanoma that, if unchecked, will circulate very rapidly by way of my physique. Doing nothing in all likelihood would make selected that I would latitude secondary tumors in a bunch of months.
Third, Drs. Apolo and Aragon-Ching strongly trust that they could furnish attention to ddMVAC with out the toxicities that have been standard 10 years within of the beyond, when 70% of victims ended up being hospitalized right by way of chemo. Dr. Apolo pronounced how she had been treating a bunch of victims who persisted to paintings, or garden, or in a the many method retain ambulatory. This helped persuade me that the 3 months of chemo in all likelihood doesn't be lost months, however that I would have the threat to retain a moderately typical agenda. Whiel I do now not predict the ddMVAC to be a cakewalk, I'm persuaded that I need to have the threat to retain away from hospitalization in final outcomes of the chemo.
Fourth, the upside of ddMVAC outweighs the downsides. The classic time for progression to full-blown tumors with out a treatment is 4-5 months. With ddMVAC, this could be over nine months, and 35% hit the 2-yr mark. While there could be no technique to prove whether or not ddMVAC sold greater time, need to that happen, it in all likelihood would now not relatively motive long run harm, principally since I'm moderately younger and in a the many method wholesome.
I've let Drs. Aragon-Ching and Apolo realise of my resolution. Dr. Aragon-Ching has got the approval of my policy cowl industrial website guests to proceed. I'll have a baseline CT scan by way of NIH on Monday afternoon, for the explanation that policy cowl industrial website guests balked at approving that. I am scheduled to have my first dose (the "M") starting on Wednesday, September 25. On Thursday, Sept. 26, I'll have the "VAC" doses. On Friday, Sept. 27, I'll have the Neulasta development hormone booster shot. Then I'll repeat the cycle for six times, or until eventually I have too many facet resultseasily (in reality mouth sores that retailer you me from swallowing). After I conclusion the cycle, I'll have an substitute CT scan to exercise routine what ameliorations there are from my baseline CT scan.
For now, I trust as I am headed back into the poisonous mire, poisoning myself to retailer myself. To (mis)quote younger Henry:
Once greater unto the breach, dear chums, in each single sector again;
Or near the cells up, make our melanoma lifeless!
In peace, there s nothing so becomes a grownup,
As modest stillness and humility:
But when the blast of chemo blows in our ears,
Then imitate the movement of the tiger;
Stiffen the sinews, summon up the blood
Disguise sincere nature with hard-favour'd rage;
Then lend the eye a awful detail;
Let pry all by way of the portage of the pinnacle
Like a brass cannon; let the foreheado'erwhelm it
As fearfully as doth a galled rock
O'erhang and jutty his confounded base
Swill'd with the wild and wasteful ocean
Now set the tooth and stretch the nostril wide
Hold hard the breath and bend up each spirit
To his full peak.